Recent Publications
Rawal, S., J.
Kim and R.A. Coulombe, Jr. (2010).
Aflatoxins in Poultry: Toxicology, Metabolism and Prevention. Research in Veterinary Science
(submitted)
Rawal, S.,
Yip, S.S.M., and R.A. Coulombe, Jr.
(2010). Cloning, Expression and Functional Characterization of Cytochrome P450
3A37 from Turkey Liver with Aflatoxin B1 Epoxidation Activity. Chemical Research in Toxicology
(submitted).
Dalloul, R.and
38 others (2010). Changing the Landscape
of Genome Sequencing: the Domestic Turkey (Meleagris gallopavo) Genome
Assembly and Analysis. PLoS Genetics (submitted).
Riley, R.T.,
Voss, K.A., Coulombe, R.A., Pestka,
J.J. and D. E. Williams (2010). Developing mechanism-based and exposure
biomarkers for mycotoxins in animals. In Determining Mycotoxins and
Mycotoxigenic Fungi in Food and Feed (S. De Saeger, ed.) Woodhead
Publishing LTD, Cambridge, UK (in press).
Kim, J.E., Bauer, M.M., Mendoza, K.M., Reed, K.M.
and R.A. Coulombe, Jr. (2010)
Comparative Genomics Identifies New Alpha Class Genes Within the Avian
Glutathione S-transferase Gene Cluster. Gene
(epub ahead of print, doi:10.1016/j.gene.2009.11.001)
Watterson, T.L., Hamilton, B., Martin, R., and R.A. Coulombe, Jr. (2009) Urban
Particulate Matter Causes ER Stress and the Unfolded Protein Reponse in Human
Lung Cells. Toxicological Sciences 112: 111-122 (doi:10.1093/toxsci/kfp186)
Rawal, S., Reed, K.M., Mendoza, K.M. and R. A. Coulombe, Jr. (2009). Structure,
genetic mapping, and function of the Cytochrome P450 3A37 gene in the turkey (Meleagris gallopavo). Cytogenetics
and Genome Research 125: 67-73.
Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2008) Butylated
Hydroxytoluene Chemoprevention of Aflatoxicosis in Turkeys: Effects On Aflatoxin B1 Bioavailability,
Hepatic DNA Adduct Formation, and Biliary Excretion In Vivo. Food and Chemical
Toxicology 46: 3727-3731 (doi:10.1016/j.fct.2008.09.050). ![]()
Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2008) Mechanisms of
butylated hydroxytoluene chemoprevention of aflatoxicosis - inhibition of
aflatoxin B1 metabolism. Toxicology and
Applied Pharmacology 227: 339-346 (DOI:10.1016/j.taap.2007.11.017).
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Watterson, T.L., Sorenson, J., Martin, R., and R.A. Coulombe, Jr. (2007). Effects of PM2.5 Collected from Cache
Valley Utah on Genes Associated with the Inflammatory Response in Human Lung
Cells. Journal of Toxicology and
Environmental Health 70:1731-1744. (DOI: 10.1080/15287390701457746) ![]()
Reed, K.M., Mendoza, K.M. and R.
A. Coulombe, Jr. (2007). Structure and genetic mapping of the Cytochrome
P4501A5 gene (CYP1A5) in the turkey (Meleagris gallopavo). Cytogenetics
and Genome Research 116:104-109. ![]()
Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2007) Butylated hydroxytoluene reduces
aflatoxin B1 bioavailability and hepatic adduct formation in turkeys. In Poisonous
Plants: Global Research and Solutions (K. Panter, T. Wierenga, J. Phister,
eds.) CAB International, London. pp. 197-202.
Coulombe, R.A. and S.M. Yip. (2007) Heterologous expression of a
cytochrome P450 from turkey liver that activates aflatoxin B1. In Poisonous Plants: Global Research and
Solutions (K. Panter, T. Wierenga, J. Phister, eds.) CAB International,
London. pp. 82-88
Yip, S.S.M. and R.A.
Coulombe, Jr. (2006) Molecular cloning and expression of a novel cytochrome
P450 from turkey liver with aflatoxin B1 metabolizing activity. Chemical Research in Toxicology
19:30-37. ![]()
Van Vleet, T.R., Watterson, T.L., Klein, P.J., and R.A. Coulombe, Jr. (2006). Aflatoxin B1
alters the expression of p53 in cytochrome P450-expressing human lung
cells. Toxicological Sciences. 89: 399-407. ![]()
Coulombe, R.A., Guarisco, J.A., Klein, P.J. and J.O. Hall (2005) Chemoprevention of
aflatoxicosis in poultry by dietary butylated hydroxytoluene. Animal
Feed Science and Technology 121: 217-225. [PDF]
Rieben, W.K., and Coulombe, R.A. (2004). DNA
cross-linking by dehydromonocrotaline lacks apparent base sequence preference. Toxicological Sciences 82, 497-503. ![]()
Coulombe, R.A. (2003) Pyrrolizidine alkaloids in foods. Advances in Food and Nutrition Research (S.L. Taylor, Ed.). Elsevier
Science Ltd., Oxford, U.K. Volume 45, pp. 61-99. [PDF]
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Coulombe, R.A., Klein, P.J. and J.O. Hall (2003). Butylated hydroxytoluene
chemoprotection: Response to Williams. Toxicology
and Applied Pharmacology 189:152. ![]()
Klein,
P.J. Van Vleet, T.R., Hall, J.O. and R.
A. Coulombe, Jr. (2003). Effect of
dietary buylated hydroxytoluene on aflatoxin B1-relevant
metabolic enzymes in turkeys. Food and
Chemical Toxicology 41:671-678. ![]()
Klein, P.J., Hall, J.O. and R.
A. Coulombe, Jr. (2003). Dietary butulated hydroxytoluene prevents
aflatoxicosis in turkeys, in Poisonous
Plants and Related Toxins (T. Acamovic,
C.S. Stewart and T.W. Pennycott eds.),
CAB International, London. pp. 478-483.
Coulombe, R.A., and W. K. Rieben (2003). Lack
of Apparent Base Sequence Preference of Activated Pyrrolizidine Alkaloid
Cross-Links with DNA, in Poisonous Plants
and Related Toxins, (T. Acamovic, C.S. Stewart and T.W. Pennycott eds.) CAB
International, London. pp. 26-31.
Van
Vleet, T R, Macé, K and R. A. Coulombe,
Jr. (2002). Comparative aflatoxin B1 activation
and cytotoxicity in human bronchial
cells expressing human CYPs 1A2 and 3A4. Cancer
Research 62, 105-112. ![]()
Van Vleet, T.R., Klein, P.J. and R. A. Coulombe, Jr. (2002). Metabolism
and cytotoxicity of aflatoxin B1 in cytochrome
P-450-expressing human lung cells. J.
Toxicology and Environmental Health, Part A 65: 853-67. ![]()
Klein,
P.J., Van Vleet, T.R., Hall, J.O. and R.
A. Coulombe, Jr. (2002). Dietary butylated hydroxytoluene protects against
aflatoxicosis in turkeys. Toxicology and
Applied Pharmacology 182, 11-19. ![]()
Klein,
P.J., Van Vleet, T.R., Hall, J.O. and R.
A. Coulombe, Jr. (2002). Biochemical factors underlying the age-related
sensitivity of turkeys to aflatoxin B1. Comparative Biochemistry and Physiology
132, 193-201. ![]()
Van Vleet, T.R., Bombick, D.W., and R.A. Coulombe, Jr. (2001) Inhibtition of Human Cytochrome P450 2E1
Activity by Nicotine, Cotinine, and Aqueous Cigarette Tar Extract in vitro. Toxicological Sciences 64,
185-191. ![]()
Van
Vleet, T.R., Klein, P.J., and R.A.
Coulombe, Jr. (2001). Metabolism of aflatoxin B1 by
Normal Human Bronchial Epithelial Cells. J.
Toxicology and Environmental Health , Part A, 63: 525-40. ![]()
Coulombe, R.A. (2001) Antioxidants
protect turkeys against toxicity of aflatoxin.
NRI Research Highlights,
National Research Initiative Competitive Grants Program, United States
Department of Agriculture, Cooperative State Research, Education and Extension
Service. No. 6. [PDF]
Klein,
P.K., Kelly, J.N., Buckner, R., and R.A.
Coulombe, Jr. (2000). Biochemical
basis for the extreme sensitivity of poultry to aflatoxin
B1. Toxicology and Applied
Pharmacology. 165:45-62. ![]()