Recent Publications   

 

Kim, J.E., Bauer, M.M., Mendoza, K.M., Reed, K.M. and R.A. Coulombe, Jr. (2009) Comparative Genomics Identifies New Alpha Class Genes Within the Avian Glutathione S-transferase Gene Cluster. Gene (submitted for publication)

 

Watterson, T.L., Hamilton, B., Martin, R., and R.A. Coulombe, Jr. (2009) Urban Particulate Matter Causes ER Stress and the Unfolded Protein Reponse in Human Lung Cells. Toxicological Sciences  112: 111-122 (doi:10.1093/toxsci/kfp186)

 

Rawal, S., Reed, K.M., Mendoza, K.M. and R. A. Coulombe, Jr. (2009). Structure, genetic mapping, and function of the Cytochrome P450 3A37 gene in the turkey (Meleagris gallopavo).  Cytogenetics and Genome Research 125: 67-73.

 

Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2008) Butylated Hydroxytoluene Chemoprevention of Aflatoxicosis in Turkeys:  Effects On Aflatoxin B1 Bioavailability, Hepatic DNA Adduct Formation, and Biliary Excretion In Vivo. Food and Chemical Toxicology 46: 3727-3731 (doi:10.1016/j.fct.2008.09.050).

 

Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2008) Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis - inhibition of aflatoxin B1 metabolism. Toxicology and Applied Pharmacology 227: 339-346 (DOI:10.1016/j.taap.2007.11.017).

 

Watterson, T.L., Sorenson, J., Martin, R., and R.A. Coulombe, Jr. (2007). Effects of PM2.5 Collected from Cache Valley Utah on Genes Associated with the Inflammatory Response in Human Lung Cells. Journal of Toxicology and Environmental Health 70:1731-1744. (DOI: 10.1080/15287390701457746)

 

Reed, K.M., Mendoza, K.M. and R. A. Coulombe, Jr. (2007). Structure and genetic mapping of the Cytochrome P4501A5 gene (CYP1A5) in the turkey (Meleagris gallopavo).  Cytogenetics and Genome Research 116:104-109.

 

Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2007) Butylated hydroxytoluene reduces aflatoxin B1 bioavailability and hepatic adduct formation in turkeys.  In Poisonous Plants: Global Research and Solutions (K. Panter, T. Wierenga, J. Phister, eds.) CAB International, London. pp. 197-202.

 

Coulombe, R.A. and S.M. Yip. (2007) Heterologous expression of a cytochrome P450 from turkey liver that activates aflatoxin B1. In Poisonous Plants: Global Research and Solutions (K. Panter, T. Wierenga, J. Phister, eds.) CAB International, London. pp. 82-88

 

Yip, S.S.M. and R.A. Coulombe, Jr. (2006) Molecular cloning and expression of a novel cytochrome P450 from turkey liver with aflatoxin B1 metabolizing activity. Chemical Research in Toxicology 19:30-37.

 

Van Vleet, T.R., Watterson, T.L., Klein, P.J., and R.A. Coulombe, Jr. (2006). Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells.  Toxicological Sciences. 89: 399-407.

 

Coulombe, R.A., Guarisco, J.A., Klein, P.J. and J.O. Hall (2005) Chemoprevention of aflatoxicosis in poultry by dietary butylated hydroxytoluene.  Animal Feed Science and Technology 121: 217-225. [PDF]

 

Rieben, W.K., and Coulombe, R.A. (2004).  DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference. Toxicological Sciences 82, 497-503.

 

Coulombe, R.A. (2003) Pyrrolizidine alkaloids in foods. Advances in Food and Nutrition Research (S.L. Taylor, Ed.). Elsevier Science Ltd., Oxford, U.K. Volume 45, pp. 61-99. [PDF]

 

Coulombe, R.A., Klein, P.J. and J.O. Hall (2003). Butylated hydroxytoluene chemoprotection: Response to Williams. Toxicology and Applied Pharmacology 189:152.

 

Klein, P.J. Van Vleet, T.R., Hall, J.O. and R. A. Coulombe, Jr.  (2003). Effect of dietary buylated hydroxytoluene on aflatoxin B1-relevant metabolic enzymes in turkeys. Food and Chemical Toxicology 41:671-678.

 

Klein, P.J., Hall, J.O. and R. A. Coulombe, Jr.  (2003).  Dietary butulated hydroxytoluene prevents aflatoxicosis in turkeys, in Poisonous Plants and Related Toxins (T. Acamovic,  C.S. Stewart and T.W. Pennycott eds.), CAB International, London. pp. 478-483.

 

Coulombe, R.A., and W. K. Rieben (2003).  Lack of Apparent Base Sequence Preference of Activated Pyrrolizidine Alkaloid Cross-Links with DNA, in Poisonous Plants and Related Toxins, (T. Acamovic, C.S. Stewart and T.W. Pennycott eds.) CAB International, London. pp. 26-31.

 

Van Vleet, T R, Macé, K and R. A. Coulombe, Jr. (2002). Comparative aflatoxin B1 activation and cytotoxicity in human bronchial cells expressing human CYPs 1A2 and 3A4. Cancer Research 62, 105-112.

 

Van Vleet, T.R., Klein, P.J. and R. A. Coulombe, Jr. (2002). Metabolism and cytotoxicity of aflatoxin B1 in cytochrome P-450-expressing human lung cells. J. Toxicology and Environmental Health, Part A 65: 853-67.

 

Klein, P.J., Van Vleet, T.R., Hall, J.O. and R. A. Coulombe, Jr. (2002). Dietary butylated hydroxytoluene protects against aflatoxicosis in turkeys. Toxicology and Applied Pharmacology 182, 11-19.

 

Klein, P.J., Van Vleet, T.R., Hall, J.O. and R. A. Coulombe, Jr. (2002). Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B1. Comparative Biochemistry and Physiology 132, 193-201.

 

Van Vleet, T.R., Bombick, D.W., and R.A. Coulombe, Jr. (2001) Inhibtition of Human Cytochrome P450 2E1 Activity by Nicotine, Cotinine, and Aqueous Cigarette Tar Extract in vitro. Toxicological Sciences 64, 185-191.

 

Van Vleet, T.R., Klein, P.J., and R.A. Coulombe, Jr. (2001). Metabolism of aflatoxin B1 by Normal Human Bronchial Epithelial Cells. J. Toxicology and Environmental Health , Part A, 63: 525-40.

 

Coulombe, R.A. (2001) Antioxidants protect turkeys against toxicity of aflatoxin.  NRI Research Highlights, National Research Initiative Competitive Grants Program, United States Department of Agriculture, Cooperative State Research, Education and Extension Service. No. 6. [PDF] 

 

Klein, P.K., Kelly, J.N., Buckner, R., and R.A. Coulombe, Jr. (2000).  Biochemical basis for the extreme sensitivity of poultry to aflatoxin B1. Toxicology and Applied Pharmacology. 165:45-62.