Recent Publications

Bunderson, B., Kim, J.E., Croasdell, A., Mendoza, K, Reed, K.M, and R.A. Coulombe, Jr. (2013) Heterologous Expression and Functional Characterization of Avian Mu-Class Glutathione S-Transferases. Comp. Biochem. Physiol. C – Toxicol Pharmacol. (in press).

Wu, Y., McEwen, G.D., Tang, M., Yu, T., Dimmick, Zhou, A., Gilbertson, T.A., Coulombe, Jr., R.A., and J.R. Stevens. (2013) Sensing Biophysical Alterations of Human Lung Cells (A549) in the Context of Toxicity Effects of Diesel Exhaust Particles. Cell Biochem Biophys (in press) DOI 10.1007/s12013-013-9618-4

Kim, J.E., Bunderson, B., Croasdell, A., Reed, K.M, and R.A. Coulombe, Jr. (2013) Alpha-class glutathione S-transferases in Wild Turkeys: Characterization and Role in Resistance to the Carcinogenic Mycotoxin Aflatoxin B1. PLOS One 8(4): e60662. doi:10.1371/journal.pone.0060662

Watterson, T.L., Hamilton, B., Martin, R., and R.A. Coulombe, Jr. (2012) Urban Particulate Matter Activates Akt in Human Lung Cells. Archives of Toxicology Jan; 86:121-135. DOI: 10.1007/s00204-011-0739-5

Kim, J.E., Bunderson, B., Croasdell, A., and R.A. Coulombe, Jr. (2011) Functional Characterization of Alpha-class Glutathione S-transferases from the Turkey (Meleagris gallopavo) Toxicological Sciences 124:45-53. doi: 10.1093/toxsci/kfr212

Rawal, S., and R.A. Coulombe, Jr. (2011). Metabolism of Aflatoxin B1 in Turkey Liver Microsomes: The Relative Roles of Cytochromes P450 A15 and 3A37. Toxicology and Applied Pharmacology 254:349-354. doi:10.1016/j.taap.2011.05.010.

Riley, R.T., Voss, K.A., Coulombe, R.A., Pestka, J.J. and D. E. Williams (2011). Developing mechanism-based and exposure biomarkers for mycotoxins in animals. In Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed (S. De Saeger, ed.) Woodhead Publishing LTD, Cambridge, UK. ISBN 978-1-84569-674-0

Rawal, S., Yip, S.S.M., and R.A. Coulombe, Jr. (2010). Cloning, Expression and Functional Characterization of Cytochrome P450 3A37 from Turkey Liver with Aflatoxin B1 Epoxidation Activity. Chemical Research in Toxicology 23:1322-1329. DOI: 10.1021/tx1000267

Rawal, S., J. Kim and R.A. Coulombe, Jr. (2010). Aflatoxins in Poultry: Toxicology, Metabolism and Prevention. Research in Veterinary Science 89:325-331. doi:10.1016/j.rvsc.2010.04.011

Dalloul, R. et al. (2010). Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo) Genome Assembly and Analysis. PLoS Biology 8(9): e1000475. doi:10.1371/journal.pbio.1000475

Kim, J.E., Bauer, M.M., Mendoza, K.M., Reed, K.M. and R.A. Coulombe, Jr. (2010) Comparative Genomics Identifies New Alpha Class Genes Within the Avian Glutathione S-transferase Gene Cluster. Gene 452:45-53 doi:10.1016/j.gene.2009.11.001

Watterson, T.L., Hamilton, B., Martin, R., and R.A. Coulombe, Jr. (2009) Urban Particulate Matter Causes ER Stress and the Unfolded Protein Reponse in Human Lung Cells. Toxicological Sciences 112: 111-122. doi:10.1093/toxsci/kfp186

Rawal, S., Reed, K.M., Mendoza, K.M. and R. A. Coulombe, Jr. (2009). Structure, genetic mapping, and function of the Cytochrome P450 3A37 gene in the turkey (Meleagris gallopavo). Cytogenetics and Genome Research 125: 67-73. doi: 10.1159/000218748

Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2008) Butylated Hydroxytoluene Chemoprevention of Aflatoxicosis in Turkeys: Effects On Aflatoxin B1 Bioavailability, Hepatic DNA Adduct Formation, and Biliary Excretion In Vivo. Food and Chemical Toxicology 46: 3727-3731 doi:10.1016/j.fct.2008.09.050

Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2008) Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis - inhibition of aflatoxin B1 metabolism. Toxicology and Applied Pharmacology 227: 339-346 DOI:10.1016/j.taap.2007.11.017

Watterson, T.L., Sorenson, J., Martin, R., and R.A. Coulombe, Jr. (2007). Effects of PM2.5 Collected from Cache Valley Utah on Genes Associated with the Inflammatory Response in Human Lung Cells. Journal of Toxicology and Environmental Health 70:1731-1744. DOI: 10.1080/15287390701457746

Reed, K.M., Mendoza, K.M. and R. A. Coulombe, Jr. (2007). Structure and genetic mapping of the Cytochrome P4501A5 gene (CYP1A5) in the turkey (Meleagris gallopavo). Cytogenetics and Genome Research 116:104-109. DOI: 10.1159/000097426

Guarisco, J.A., Hall, J.O., and R.A. Coulombe, Jr. (2007) Butylated hydroxytoluene reduces aflatoxin B1 bioavailability and hepatic adduct formation in turkeys. In Poisonous Plants: Global Research and Solutions (K. Panter, T. Wierenga, J. Phister, eds.) CAB International, London. pp. 197-202.

Coulombe, R.A. and S.M. Yip. (2007) Heterologous expression of a cytochrome P450 from turkey liver that activates aflatoxin B1. In Poisonous Plants: Global Research and Solutions (K. Panter, T. Wierenga, J. Phister, eds.) CAB International, London. pp. 82-88

Yip, S.S.M. and R.A. Coulombe, Jr. (2006) Molecular cloning and expression of a novel cytochrome P450 from turkey liver with aflatoxin B1 metabolizing activity. Chemical Research in Toxicology 19:30-37. DOI: 10.1021/tx050233+

Van Vleet, T.R., Watterson, T.L., Klein, P.J., and R.A. Coulombe, Jr. (2006). Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells. Toxicological Sciences. 89: 399-407. doi: 10.1093/toxsci/kfj039

Coulombe, R.A., Guarisco, J.A., Klein, P.J. and J.O. Hall (2005) Chemoprevention of aflatoxicosis in poultry by dietary butylated hydroxytoluene. Animal Feed Science and Technology 121: 217-225. [PDF] Doi: 10.1016/J.Anifeedsci.2005.03.001

Rieben, W.K., and Coulombe, R.A. (2004). DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference. Toxicological Sciences 82, 497-503. doi: 10.1093/toxsci/kfh262

Coulombe, R.A. (2003) Pyrrolizidine alkaloids in foods. Advances in Food and Nutrition Research (S.L. Taylor, Ed.). Elsevier Science Ltd., Oxford, U.K. Volume 45, pp. 61-99. [PDF] http://dx.doi.org/10.1016/S1043-4526(03)45003-1

Klein, P.J. Van Vleet, T.R., Hall, J.O. and R. A. Coulombe, Jr. (2003). Effects of dietary buylated hydroxytoluene on aflatoxin B1-relevant metabolic enzymes in turkeys. Food and Chemical Toxicology 41:671-678. doi:10.1016/S0278-6915(02)00332-0